Advice for fun/balanced settings for Quest mode?

It's awesome that Forge offers such a wide range of customization options for Quest mode, but it's kind of intimidating for the first timer.
Any advice as to what settings will give the most fun and balanced experience in your opinion? Looking over the Quest options it seems like it would be kind of a slow grind to unlock new cards and sets at default settings.
Also, when it comes to starting sets, is it generally a better idea to start with a block (like, say, Ice Age/Alliances/Coldsnap) and then gradually unlock other sets instead of just having the whole card pool from the start?
Any advice as to what settings will give the most fun and balanced experience in your opinion? Looking over the Quest options it seems like it would be kind of a slow grind to unlock new cards and sets at default settings.
Also, when it comes to starting sets, is it generally a better idea to start with a block (like, say, Ice Age/Alliances/Coldsnap) and then gradually unlock other sets instead of just having the whole card pool from the start?